Monk

 When this show came out I watched a few episodes and fell for the superficiality of the premise-look at that man with a mental disorder-how funny! It falls into the same trap as Big Bang Theory, where someone who clearly has a different brain is made fun off by his friends for it, and in this case, is the cause of frustration to all who know him. But beneath this veneer of low comedy, there's a compelling portrayal of a very troubled man. There's one episode where you can see how deeply unhappy he is, and usually his suffering is a joke in the series.  It was well acted and written,.  There's another time a culprit that Monk catches says, 'are you happy now?' and he says, No, but this is as good as it gets.  There's another scence where he is tortured at the dentist that is chlling.  I think you could do cut of the series without the quirky music and it would work as a thriller.